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TB-500, 10mg, lyophilized research peptide vial, Eppix Labs
Certificate of Analysis — 10mgCertificate of Analysis for TB-500 10mg
Chemical StructureTB-500 chemical structure
Amino Acid SequenceTB-500 amino acid chain
Latest COA

Buy TB-500 Canada | Thymosin Beta-4 10mg

Janoshik

Batch TB5-CA-26F-10

Result2026-06-29
Added2026-08-01
Avg Purity99.182%
Avg Mass11.52 mg
Verify on Janoshik
In StockResearch Peptide
BatchTB5-CA-26F-10

Buy TB-500 Canada | Thymosin Beta-4 10mg

Thymosin Beta-4 Fragment Research Peptide

TB-500 is a synthetic peptide studied in laboratory settings for its role in cellular migration and tissue remodeling pathways. Research commonly explores its influence on cytoskeletal organization, regenerative signaling processes, and overall structural repair mechanisms in controlled experimental models.

$65.00CAD
Purity VerifiedLab TestedSecure
Research Use Only

This product is intended strictly for laboratory research use within Canada. It is not approved by Health Canada for the diagnosis, treatment, cure, or prevention of any disease. Not for human or veterinary use.

By purchasing, you confirm the material will be used solely for lawful research purposes in accordance with applicable Canadian regulations.

TB-500 is a synthetic research peptide modeled after thymosin beta-4, a naturally occurring peptide involved in cellular signaling processes. It is developed for controlled laboratory investigation within regulated experimental environments.

In scientific literature, TB-500 is studied in experimental models examining cellular migration pathways, cytoskeletal organization, and structural signaling frameworks under in vitro and preclinical research conditions.

Amino Acid Sequence
Amino acid chain diagram
Chemical Structure
Chemical structure diagram
Compound Properties
CAS Number77591-33-4
Molecular FormulaC212H350N56O78S
Molecular Weight4963.44 g/mol
PubChem CID16132341

Overview

TB-500 is a synthetic analogue related to thymosin beta-4, a peptide involved in actin-binding and cellular structural regulation. Research has examined its interaction with cytoskeletal signaling pathways and cellular migration systems within controlled laboratory environments.

Experimental studies evaluate peptide behavior in structural pathway models and tissue-related signaling frameworks under in vitro and preclinical research conditions.

History

Thymosin beta-4 was initially identified during investigations into thymic peptides and immune-related signaling systems. Subsequent research expanded into studies of actin-binding activity and cellular structural regulation.

TB-500 emerged as a synthetic research analogue used in experimental models evaluating structural pathway interaction and cellular communication systems.

Key Research Areas

Laboratory investigations into TB-500 have focused on cytoskeletal interaction models and cellular migration pathways. Research frameworks evaluate actin-binding dynamics, structural signaling mechanisms, and peptide-mediated cellular response systems under controlled in vitro and preclinical conditions.

1 of the 4 areas below are addressed directly by a paper cited on this page.

Cytoskeletal signaling pathway models

No paper cited on this page reports on cytoskeletal. This heading marks where TB-500 is discussed in the category rather than a question the cited literature answers, and it is worth knowing which of these areas has work behind it and which does not.

Cellular migration research frameworks

Addressed on this page by Bock-Marquette 2004. The work appeared in Nature. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.

  • Bock-Marquette, I. et al. (2004) Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature 432(7016):466–472.

Actin-binding interaction studies

No paper cited on this page reports on actin, binding or interaction. This heading marks where TB-500 is discussed in the category rather than a question the cited literature answers, and it is worth knowing which of these areas has work behind it and which does not.

Structural pathway regulation investigations

No paper cited on this page reports on structural or regulation. This heading marks where TB-500 is discussed in the category rather than a question the cited literature answers, and it is worth knowing which of these areas has work behind it and which does not.

The references section of this page cites 3 primary papers published between 1999 and 2007 — a thin record. Every citation is linked to its PubMed or DOI record so it can be read rather than taken on trust, and the summaries above describe what those papers report rather than what the compound is claimed to do.

Research compounds attract claims that outrun their evidence. Below are the ones most often encountered for TB-500, set against what the papers cited on this page actually report. Where the record is thin or contested, that is stated rather than smoothed over.

Also called

TB-500 is also referred to as TB4, thymosin beta-4 fragment, TB.

Preclinical only

Described online as a healing and recovery compound for soft tissue injury.

TB-500 is a synthetic fragment of thymosin beta-4, a naturally occurring actin-sequestering protein. The published work on tissue repair examines thymosin beta-4 and its fragments in animal and cell-culture models, centred on actin binding, cell migration and angiogenesis. No controlled human efficacy trial of TB-500 for injury recovery has been published.

Contested

Used interchangeably with thymosin beta-4, as though they are the same thing.

They are related but not identical. Thymosin beta-4 is a 43-residue protein; TB-500 as supplied for research is a short synthetic fragment corresponding to its actin-binding region. Much of the literature invoked in support of TB-500 was carried out on the full protein, and findings from one do not transfer automatically to the other. The structural detail published on this page is for the fragment actually supplied.

Not supported

Described as safe for long-term use.

No human clinical safety data has been published for TB-500. Its proposed mechanism includes promotion of angiogenesis, which is the same property that has prompted caution in the wider literature on repair-model peptides. It is not approved for human use by any regulatory agency.

Nothing above is a statement of what this material does. It is a summary of what has been published and what has not. Eppix Labs supplies research materials only and provides no dosing, administration or protocol guidance.

Verification for TB-500 is per lot, not per product. The current 10mg lot TB5-CA-26F-10 returned 99.182% purity, 11.52 mg measured, 115.2% of the labelled 10 mg, assayed by Janoshik. Those figures are the laboratory's, published in full rather than reduced to a badge.

Purity is half the number. It states what fraction of the material in the vial is TB-500; it says nothing about how much material is in the vial, and a short-filled vial can return a purity result that is entirely accurate. The figure that answers the second question is measured mass against expected content — for TB-500, this lot measured 115.2% of its labelled 10 mg. Both numbers are published for every lot, whichever way they fall.

The lot code printed on the vial matches the code on the certificate for TB-500. Matching the two is what confirms the unit in hand came from the batch that was tested — a certificate not tied to a lot code proves nothing about any particular unit.

Researchers who buy TB-500 in Canada through Eppix Labs receive the lot described by the certificate above: the code printed on the vial label is the code on the certificate, and both are searchable on the batch verification page.

Verify a batch code →

Lyophilized storage
−20 °C long-term; stable at room temperature in transit
After reconstitution
2–8 °C
Light
Protect from UV and direct light
Freeze-thaw
Avoid repeated cycles
Vehicle
Bacteriostatic water in most published protocols
Format
Lyophilized powder

TB-500 is supplied as lyophilized powder. In the dry state the material is comparatively stable, which is why it ships at ambient temperature without a cold chain; once reconstituted it is a peptide in solution and the handling constraints tighten considerably. At 43 residues it is short enough to be produced by solid-phase synthesis, and the published sequence on this page is what an identity assay is checked against.

Repeated freeze-thaw cycling is the handling error most likely to degrade material of this class, because each cycle concentrates solutes at the ice boundary. Where a protocol calls for the same vial across multiple sessions, the published literature generally describes aliquoting after reconstitution rather than re-freezing the whole volume.

Vials may appear empty on arrival. Lyophilized material collects at the base of the vial and is often not visible until the vial is inspected under direct light.

Reconstitution calculator →

Included
  • 1 × sealed glass vial in the strength selected (10mg / Single Vial, 10mg / 5-Pack, 10mg / 10-Pack available), batch-labelled
  • The batch-linked Certificate of Analysis for the exact lot shipped
  • Discreet outer packaging with no product names on the exterior
  • Canada Post Xpress, tracked, typically 1–2 business days from Alberta
Not included
  • Bacteriostatic water or any other reconstitution vehicle
  • Syringes, needles or filters
  • Dosing, administration or protocol guidance of any kind

Reconstitution materials are sourced separately. The reconstitution calculator on this site works out concentrations for a given volume, but it is an arithmetic tool for laboratory record-keeping and not a protocol.

No. Eppix Labs products are supplied exclusively for laboratory research. We do not provide dosing, administration, or usage guidance.

Each vial contains 10mg of lyophilized TB-500. Independent third-party testing verifies purity, identity, and net content per batch.

The vial contains only the peptide preparation. Any laboratory materials required for experimental procedures must be sourced separately.

Duration depends entirely on research protocol, storage conditions, and laboratory application.

Malinda, K.M. et al.(1999)

Thymosin beta4 accelerates wound healing. J Invest Dermatol 113(3):364–368.

PubMed
Bock-Marquette, I. et al.(2004)

Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature 432(7016):466–472.

PubMed
Smart, N. et al.(2007)

Thymosin beta 4 induces adult epicardial progenitor mobilization and neovascularization.

PubMed

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