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MOTS-c, 10mg, lyophilized research peptide vial, Eppix Labs
Certificate of Analysis — 10mgCertificate of Analysis for MOTS-c 10mg
Chemical StructureMOTS-c chemical structure
Amino Acid SequenceMOTS-c amino acid chain
Latest COA

Buy MOTS-c Canada | Mitochondrial Peptide

Janoshik

Batch MOTS-CA-26F-10

Result2026-06-26
Added2026-08-01
Avg Purity98.683%
Avg Mass11.20 mg
Verify on Janoshik
In StockLongevity
BatchMOTS-CA-26F-10

Buy MOTS-c Canada | Mitochondrial Peptide

Mitochondrial-Derived Peptide

MOTS-c is a mitochondrial-derived peptide studied in laboratory research for its involvement in cellular energy regulation and metabolic signaling pathways. Research often focuses on its interaction with mitochondrial function, stress-response mechanisms, and pathways related to cellular homeostasis in controlled experimental models.

$45.00CAD
Purity VerifiedLab TestedSecure
Research Use Only

This product is intended strictly for laboratory research use within Canada. It is not approved by Health Canada for the diagnosis, treatment, cure, or prevention of any disease. Not for human or veterinary use.

By purchasing, you confirm the material will be used solely for lawful research purposes in accordance with applicable Canadian regulations.

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a mitochondrial-derived peptide identified through genomic analysis of mitochondrial DNA. It is synthesized for controlled laboratory research and studied within experimental environments focused on cellular and metabolic signaling.

In scientific literature, MOTS-c is examined for its interaction with metabolic regulation pathways, mitochondrial signaling mechanisms, and stress-response models under in vitro and preclinical research conditions.

Amino Acid Sequence
Amino acid chain diagram
Chemical Structure
Chemical structure diagram
Compound Properties
CAS Number1627580-64-6
Molecular FormulaC101H152N28O22S2
Molecular Weight2174.6 g/mol
PubChem CID146675088

Overview

MOTS-c is a 16-amino acid peptide encoded within mitochondrial DNA and identified in 2015 as part of the expanding class of mitochondrial-derived peptides. Unlike nuclear-encoded peptides, MOTS-c originates from the mitochondrial genome and has been studied for its role in intracellular communication and metabolic pathway regulation.

Research has examined its interaction with AMPK-related pathways, cellular stress response systems, and metabolic signaling frameworks under controlled experimental conditions.

History

MOTS-c was first characterized in 2015 during investigations into small open reading frames encoded by mitochondrial DNA. Its discovery contributed to the recognition of mitochondria as signaling organelles beyond their traditional bioenergetic role.

Subsequent research expanded into metabolic regulation and cellular stress-response models within preclinical laboratory studies.

Key Research Areas

Laboratory investigations into MOTS-c have explored its involvement in mitochondrial signaling and metabolic regulation pathways. Research models examine intracellular communication mechanisms, AMPK-associated signaling, and stress-response modulation under controlled in vitro and preclinical conditions.

2 of the 4 areas below are addressed directly by a paper cited on this page.

Mitochondrial-derived peptide signaling

Addressed on this page by Lee 2015, Kim 2017, Cobb 2016. The work appeared in Aging (Albany NY). Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.

  • Lee, C. et al. (2015) The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.
  • Kim, S.J. et al. (2017) Mitochondrially derived peptides as novel regulators of metabolism.
  • Cobb, L.J. et al. (2016) Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. Aging (Albany NY) 8(4):796–809.

AMPK pathway interaction models

No paper cited on this page reports on ampk or interaction. This heading marks where MOTS-c is discussed in the category rather than a question the cited literature answers, and it is worth knowing which of these areas has work behind it and which does not.

Cellular stress-response research

No paper cited on this page reports on cellular, stress or response. This heading marks where MOTS-c is discussed in the category rather than a question the cited literature answers, and it is worth knowing which of these areas has work behind it and which does not.

Metabolic regulation frameworks

Addressed on this page by Lee 2015. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.

  • Lee, C. et al. (2015) The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.

The references section of this page cites 5 primary papers published between 2015 and 2021 — a limited but non-trivial record. Every citation is linked to its PubMed or DOI record so it can be read rather than taken on trust, and the summaries above describe what those papers report rather than what the compound is claimed to do.

Research compounds attract claims that outrun their evidence. Below are the ones most often encountered for MOTS-c, set against what the papers cited on this page actually report. Where the record is thin or contested, that is stated rather than smoothed over.

Also called

MOTS-c is also referred to as MOTS.

Preclinical only

Described as an exercise-mimetic that improves metabolism.

MOTS-c is a mitochondrial-derived peptide encoded in mitochondrial rather than nuclear DNA, and the published work examines its role in metabolic regulation largely in cell culture and rodent models. The exercise-related framing comes from animal studies reporting effects on physical performance measures. No controlled human efficacy trial has been published.

Nothing above is a statement of what this material does. It is a summary of what has been published and what has not. Eppix Labs supplies research materials only and provides no dosing, administration or protocol guidance.

Verification for MOTS-c is per lot, not per product. Across the strengths currently stocked: 10mg lot MOTS-CA-26F-10 returned 98.683% purity, 11.2 mg measured, 112% of the labelled 10 mg; 20mg lot MOTS-CA-26F-20 returned 99.281% purity, 22.94 mg measured, 114.7% of the labelled 20 mg; 40mg lot MOTS-CA-26G-40 returned 99.252% purity, 46.13 mg measured, 115.3% of the labelled 40 mg, assayed by Janoshik. Those figures are the laboratory's, published in full rather than reduced to a badge.

Purity is half the number. It states what fraction of the material in the vial is MOTS-c; it says nothing about how much material is in the vial, and a short-filled vial can return a purity result that is entirely accurate. The figure that answers the second question is measured mass against expected content — for MOTS-c, across the strengths stocked they run from 112% to 115.3% of label. Both numbers are published for every lot, whichever way they fall.

Each strength of MOTS-c carries its own lot code and its own certificate — MOTS-CA-26F-10, MOTS-CA-26F-20, MOTS-CA-26G-40 are separate tests, not one result applied across the range. The code printed on the vial you receive is the one to match, and matching it is what ties the material in hand to a test that was actually run on it.

Researchers who buy MOTS-c in Canada through Eppix Labs receive the lot described by the certificate above: the code printed on the vial label is the code on the certificate, and both are searchable on the batch verification page.

Verify a batch code →

Lyophilized storage
−20 °C long-term; stable at room temperature in transit
After reconstitution
2–8 °C
Light
Protect from UV and direct light
Freeze-thaw
Avoid repeated cycles
Vehicle
Bacteriostatic water in most published protocols
Format
Lyophilized powder

MOTS-c is supplied as lyophilized powder. In the dry state the material is comparatively stable, which is why it ships at ambient temperature without a cold chain; once reconstituted it is a peptide in solution and the handling constraints tighten considerably. At 16 residues it is short enough to be produced by solid-phase synthesis, and the published sequence on this page is what an identity assay is checked against.

Repeated freeze-thaw cycling is the handling error most likely to degrade material of this class, because each cycle concentrates solutes at the ice boundary. Where a protocol calls for the same vial across multiple sessions, the published literature generally describes aliquoting after reconstitution rather than re-freezing the whole volume.

Vials may appear empty on arrival. Lyophilized material collects at the base of the vial and is often not visible until the vial is inspected under direct light.

Reconstitution calculator →

Included
  • 1 × sealed glass vial in the strength selected (20mg / Single Vial, 40mg / Single Vial, 10mg / Single Vial, 20mg / 5-Pack, 20mg / 10-Pack, 40mg / 5-Pack, 40mg / 10-Pack, 10mg / 5-Pack, 10mg / 10-Pack available), batch-labelled
  • The batch-linked Certificate of Analysis for the exact lot shipped
  • Discreet outer packaging with no product names on the exterior
  • Canada Post Xpress, tracked, typically 1–2 business days from Alberta
Not included
  • Bacteriostatic water or any other reconstitution vehicle
  • Syringes, needles or filters
  • Dosing, administration or protocol guidance of any kind

Reconstitution materials are sourced separately. The reconstitution calculator on this site works out concentrations for a given volume, but it is an arithmetic tool for laboratory record-keeping and not a protocol.

No. Eppix Labs products are supplied exclusively for laboratory research. We do not provide dosing, administration, or usage guidance.

Each vial contains the labeled quantity (10mg or 45mg) of lyophilized MOTS-c. Independent third-party testing verifies purity, identity, and net content per batch.

The vial contains only the lyophilized compound. Any laboratory materials required for reconstitution or experimental procedures must be sourced separately.

Duration depends entirely on research protocol, storage conditions, and laboratory application.

Lee, C. et al.(2015)

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.

PubMed
Kim, S.J. et al.(2017)

Mitochondrially derived peptides as novel regulators of metabolism.

PubMed
Reynolds, J.C. et al.(2021)

MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis.

PubMed
Cobb, L.J. et al.(2016)

Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. Aging (Albany NY) 8(4):796–809.

PubMed
Merry, T.L. et al.(2020)

Mitochondrial-derived peptides in energy metabolism.

PubMed

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