CJC-1295 and Ipamorelin in Canada: The Blend, and What Each Half Does

CJC-1295 is a modified fragment of growth-hormone-releasing hormone, GHRH(1-29), with four amino-acid substitutions that resist enzymatic degradation. It acts at the GHRH receptor. The name is used for two distinct molecules, which is the single biggest source of confusion in this category, and the distinction is covered in the next section.

Ipamorelin is a synthetic pentapeptide ghrelin-receptor (GHS-R1a) agonist, described by Raun et al. (1998) as the first selective growth hormone secretagogue: it stimulated GH release in their models without the prolactin and ACTH elevation seen with earlier secretagogues.[3]

The two therefore engage different receptors on the same axis, which is why they are studied together.

Research Material

CJC-1295 with DAC carries a Drug Affinity Complex, a maleimidoproprionic acid linker that binds covalently to serum albumin and extends the half-life to roughly a week. This is the molecule from the published human pharmacokinetic work: Teichman et al. (2006) reported sustained GH and IGF-1 elevation over days after single administration,[1] and Ionescu and Frohman (2006) reported that GH secretion remained pulsatile under continuous stimulation.[2]

CJC-1295 without DAC, correctly called mod GRF 1-29, is the same modified GHRH fragment without the linker, with a half-life measured in minutes rather than days. It is the form usually supplied in blends, because a short-acting GHRH analogue pairs sensibly with a short-acting secretagogue.

These are not interchangeable, they have different masses, and the published pharmacokinetics attach to only one of them. A supplier that does not state which one is in the vial has not told you what you are buying.

CJC-1295 no-DAC is a 29-residue peptide near 3368 Da; ipamorelin is a pentapeptide near 712 Da. The mass difference is large, which is convenient: a mass-spectrometry report on a blend can resolve both components cleanly, and a missing or wrong component is obvious.

Amino Acid Sequence

Chemical Structure

Each compound separately, because that is how the work was done:

• ·CJC-1295 with DAC, human pharmacokinetics. Teichman et al. (2006): single subcutaneous administration in healthy adults produced sustained increases in GH and IGF-1 over several days.[1]
• ·Pulsatility preserved. Ionescu and Frohman (2006): under continuous GHRH-receptor stimulation by CJC-1295, GH secretion remained pulsatile rather than flattening, which was the mechanistically interesting result.[2]
• ·Ipamorelin selectivity. Raun et al. (1998): GH release in rat and swine models with a selectivity profile distinguishing it from earlier secretagogues.[3]
• ·Ipamorelin in bone models. Johansen et al. (1999) reported longitudinal bone growth in rats,[4] and Andersen et al. (2001) reported counteraction of glucocorticoid-induced decrease in bone formation in adult rats.[5]

CJC-1295 with DAC has published early-phase human pharmacokinetic data and no efficacy trials. Ipamorelin reached early clinical investigation and was not developed further. The no-DAC form supplied in most blends has essentially no human literature of its own. Neither compound is approved anywhere, and there is no published trial of the blend as a blend.

Reading DAC pharmacokinetics onto a no-DAC vial is the specific error this category invites. The half-lives differ by orders of magnitude.

A single-compound certificate reports one purity figure and one measured mass. A blend certificate cannot: HPLC purity is defined against a single analyte, so a two-component vial is reported instead as two measured masses, one per component, with identity confirmed for each. A blend certificate showing a single purity percentage has either tested only one component or is reporting something that does not mean what it appears to mean.

What to look for on an Eppix blend certificate: both components named, both masses measured against their labelled amounts, identity confirmed for each, and the batch number matching the vial. The certificate is published before sale and verifiable on Janoshik's own database.

Published Certificate

Select strength

5mg10mg20mg

Batch

CJIP-CA-26A-01

Purity (HPLC)

Not reported

Measured content

Not reported

Laboratory

Not reported

Verify on the lab’s own databaseAll published certificates

Domestic fulfilment is by Canada Post Xpresspost, typically one to two days nationwide, free over $200, with an Interac e-Transfer discount and mix-and-match pricing at 5 and 10 vials.

Ipamorelin is also supplied on its own, and the single-compound guide is at buy ipamorelin in Canada. Other GH-axis compounds are covered in buy tesamorelin in Canada and buy sermorelin in Canada.

Available at Eppix Labs

CJC-1295 Ipamorelin Blend Canada

5mg · 10mg · 20mg

Every batch tested by an independent laboratory, with the certificate published before sale.

From $60.00 CADIn stock