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Melanotan II Spray, 10mg, lyophilized research peptide vial, Eppix Labs
Certificate of Analysis — 10mgCertificate of Analysis for Melanotan II Spray 10mg
Chemical StructureMelanotan II Spray chemical structure
Amino Acid SequenceMelanotan II Spray amino acid chain
Latest COA

Melanotan II Spray10mg

Batch
MT2-CA-26F-10
Tested by
Janoshik
Tested on
2026-07-13
Added
2026-08-04
Avg Purity99.887%
Avg Mass11.12 mg
Verify on Janoshik
CAS
121062-08-6
Formula
C50H69N15O9
Mol. weight
1024.18 g/mol
Form
Pre-mixed solution
Storage
Refrigerated, 2–8 °C
Tested by
Janoshik
Low on StockNasal Sprays
BatchMT2-CA-26F-10

Melanotan II Spray

Melanotan II Spray Canada — Nasal Spray

Melanocortin Receptor Research Peptide — Nasal Spray

Melanotan II is a synthetic cyclic peptide analogue derived from alpha-melanocyte–stimulating hormone (α-MSH). It is developed for controlled laboratory research involving melanocortin receptor signaling systems.

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Research Use Only

This product is intended strictly for laboratory research use within Canada. It is not approved by Health Canada for the diagnosis, treatment, cure, or prevention of any disease. Not for human or veterinary use.

By purchasing, you confirm the material will be used solely for lawful research purposes in accordance with applicable Canadian regulations.

Melanotan II is a synthetic cyclic peptide analogue derived from alpha-melanocyte–stimulating hormone (α-MSH). It is developed for controlled laboratory research involving melanocortin receptor signaling systems.

In scientific literature, Melanotan II is studied in experimental models examining melanocortin receptor interaction, neuroendocrine signaling pathways, and receptor-mediated regulatory mechanisms under in vitro and preclinical research conditions.

Purity

Third-party tested for purity, ID, quantity.

Amino Acid Sequence
Amino acid chain diagram
Chemical Structure
Chemical structure diagram
Compound Properties
CAS Number121062-08-6
Molecular FormulaC50H69N15O9
Molecular Weight1024.18 g/mol
PubChem CID92432

Overview

Melanotan II is a cyclic melanocortin receptor agonist evaluated in research focused on melanocortin pathway signaling and receptor interaction dynamics. Experimental studies examine its interaction within neuroendocrine regulatory systems and melanocortin-associated signaling frameworks under controlled laboratory conditions.

Research publications have explored its receptor-binding profile and pathway-level signaling characteristics within structured experimental environments.

History

Melanotan II originated from research into melanocortin receptor agonists derived from α-MSH analogues. Structural modifications led to the development of cyclic peptides designed to enhance receptor interaction properties for experimental study.

Subsequent investigations documented its receptor subtype interaction and signaling behavior in laboratory research models.

Key Research Areas

Laboratory investigations into Melanotan II have focused on melanocortin receptor activation models and neuroendocrine signaling pathways. Research frameworks evaluate receptor-mediated interaction, melanocortin pathway dynamics, and peptide-associated regulatory systems under controlled in vitro and preclinical conditions.

2 of the 4 areas below are addressed directly by a paper cited on this page.

Melanocortin receptor activation models

Addressed on this page by Eliason 2022, Yue 2023. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.

  • Eliason, N.L. et al. (2022) — Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food.
  • Yue, W.K. et al. (2023) — Targeting Melanocortin Receptors Using SNAr-Type Macrocyclization: A Doubly Orthogonal Route to Cyclic Peptide Conjugates.

Neuroendocrine signaling pathway studies

No paper cited on this page reports on neuroendocrine. This heading marks where Melanotan II Spray is discussed in the category rather than a question the cited literature answers, and it is worth knowing which of these areas has work behind it and which does not.

α-MSH analogue research frameworks

No paper cited on this page reports on analogue. This heading marks where Melanotan II Spray is discussed in the category rather than a question the cited literature answers, and it is worth knowing which of these areas has work behind it and which does not.

Receptor subtype interaction investigations

Addressed on this page by Eliason 2022, Yue 2023. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.

  • Eliason, N.L. et al. (2022) — Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food.
  • Yue, W.K. et al. (2023) — Targeting Melanocortin Receptors Using SNAr-Type Macrocyclization: A Doubly Orthogonal Route to Cyclic Peptide Conjugates.

The references section of this page cites 5 primary papers published between 2022 and 2024 — a limited but non-trivial record. Every citation is linked to its PubMed or DOI record so it can be read rather than taken on trust, and the summaries above describe what those papers report rather than what the compound is claimed to do.

Research compounds attract claims that outrun their evidence. Below are the ones most often encountered for Melanotan II Spray, set against what the papers cited on this page actually report. Where the record is thin or contested, that is stated rather than smoothed over.

Also called

Melanotan II Spray is also referred to as MT-2, MT2, melanotan 2.

Preclinical only

Melanotan II Spray is commonly described online in connection with increased libido and sexual function. In the research literature the same compound is filed under melanocortin receptor activation models, neuroendocrine signaling pathway studies and α-MSH analogue research frameworks.

The 5 papers cited on this page, published between 2022 and 2024 (1 in animal models) describe laboratory and animal work. None reports a controlled trial in humans. Findings in cell culture or in a rodent model describe what happened in that system; they do not establish that the same occurs in humans, and this compound is not approved for human use.

Nothing above is a statement of what this material does. It is a summary of what has been published and what has not. Eppix Labs supplies research materials only and provides no dosing, administration or protocol guidance.

Verification for Melanotan II Spray is per lot, not per product. The current 10mg lot MT2-CA-26F-10 returned 99.887% purity, 11.12 mg measured, 111.2% of the labelled 10 mg, assayed by Janoshik. Those figures are the laboratory's, published in full rather than reduced to a badge.

The lot code printed on the vial matches the code on the certificate for Melanotan II Spray. Matching the two is what confirms the unit in hand came from the batch that was tested — a certificate not tied to a lot code proves nothing about any particular unit.

Researchers who buy Melanotan II Spray in Canada through Eppix Labs receive the lot described by the certificate above: the code printed on the vial label is the code on the certificate, and both are searchable on the batch verification page.

Verify a batch code →

Storage
Refrigerated, 2–8 °C
Light
Protect from UV and direct light
Reconstitution
Not applicable — supplied in solution
Format
Pre-mixed solution

Melanotan II Spray ships as a prepared solution rather than as lyophilized powder, so it is already past the point at which a powder would be reconstituted. That shortens handling but tightens storage: a compound in solution is less stable than the same compound dry, and refrigeration from arrival onward is the relevant control.

The stability window for a solution is shorter than the shelf life of a sealed lyophilized vial of the same compound. Records for laboratory work in this format should note the date the unit was opened, not only the date it was received.

Vials may appear empty on arrival. Lyophilized material collects at the base of the vial and is often not visible until the vial is inspected under direct light.

Reconstitution calculator →

Included
  • 1 × sealed spray unit (10mL - 100 mcg per spray / Single Vial), batch-labelled
  • The batch-linked Certificate of Analysis for the exact lot shipped
  • Discreet outer packaging with no product names on the exterior
  • Canada Post Xpresspost, tracked, typically 1–2 business days from Canadian stock
Not included
  • Laboratory consumables of any kind
  • Dosing, administration or protocol guidance of any kind

No. Eppix Labs products are supplied exclusively for laboratory research. We do not provide dosing, administration, or usage guidance.

Each vial contains 10mg of lyophilized Melanotan II. Independent third-party testing verifies purity, identity, and net content per batch.

The vial contains only the peptide preparation. Any laboratory materials required for experimental procedures must be sourced separately.

Duration depends entirely on research protocol, storage conditions, and laboratory application.

Liu, H. et al.(2024)

Therapeutic Strategies Against Metabolic Imbalance in a Male Mouse Model With 5-HT2CR Loss-of-Function.

PubMed
Todorovic, M. et al.(2024)

5-Hydroxypyrroloindoline Affords Tryptathionine and 2,2′-bis-Indole Peptide Staples: Application to Melanotan-II.

PubMed
Wekwejt, P. et al.(2023)

Melanotan-II reverses memory impairment induced by a short-term HF diet.

PubMed
Eliason, N.L. et al.(2022)

Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food.

PubMed
Yue, W.K. et al.(2023)

Targeting Melanocortin Receptors Using SNAr-Type Macrocyclization: A Doubly Orthogonal Route to Cyclic Peptide Conjugates.

PubMed

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Support

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