Synthetic Tetrapeptide Research Compound — Nasal Spray
Epitalon, also known in scientific literature as Epithalon, is a synthetic tetrapeptide composed of alanine–glutamic acid–aspartic acid–glycine (Ala-Glu-Asp-Gly). It is developed for controlled laboratory research involving peptide-mediated regulatory systems.
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Research Use Only
This product is intended strictly for laboratory research use within Canada. It is not approved by Health Canada for the diagnosis, treatment, cure, or prevention of any disease. Not for human or veterinary use.
By purchasing, you confirm the material will be used solely for lawful research purposes in accordance with applicable Canadian regulations.
Epitalon, also known in scientific literature as Epithalon, is a synthetic tetrapeptide composed of alanine–glutamic acid–aspartic acid–glycine (Ala-Glu-Asp-Gly). It is developed for controlled laboratory research involving peptide-mediated regulatory systems.
In experimental models, Epitalon is studied in frameworks examining cellular signaling pathways, telomere-associated research systems, and regulatory peptide interaction mechanisms under in vitro and preclinical research conditions.
Epitalon is a short synthetic peptide evaluated in research focused on regulatory peptide signaling systems and telomere-associated biological frameworks. Experimental studies examine its interaction within cellular signaling environments and peptide-mediated pathway models under controlled laboratory conditions.
Research publications have explored its role in cellular regulatory systems and telomerase-associated research frameworks within structured experimental settings.
History
Epitalon was developed through investigations into short regulatory peptides derived from pineal gland research. Early experimental work examined its biochemical properties and signaling characteristics in laboratory models.
Subsequent research expanded into studies exploring peptide-mediated regulatory systems and telomere-associated pathway interaction frameworks.
Key Research Areas
Laboratory investigations into Epitalon have focused on regulatory peptide signaling models and telomere-associated pathway research systems. Research frameworks evaluate peptide interaction within cellular regulatory environments and signaling cascades under controlled in vitro and preclinical conditions.
2 of the 4 areas below are addressed directly by a paper cited on this page.
Regulatory peptide signaling models
Addressed on this page by Araj 2025, Khavinson 2020, Caputi 2019. The work appeared in Int J Mol Sci. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.
Araj, S.K. et al. (2025) — Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties. Int J Mol Sci 26(6):2509.
Khavinson, V. et al. (2020) — AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism.
No paper cited on this page reports on telomere or associated. This heading marks where Epitalon Spray is discussed in the category rather than a question the cited literature answers, and it is worth knowing which of these areas has work behind it and which does not.
Cellular signaling framework investigations
No paper cited on this page reports on cellular. This heading marks where Epitalon Spray is discussed in the category rather than a question the cited literature answers, and it is worth knowing which of these areas has work behind it and which does not.
Short peptide interaction studies
Addressed on this page by Caputi 2019, Araj 2025, Khavinson 2020. The work appeared in Int J Mol Sci. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.
Araj, S.K. et al. (2025) — Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties. Int J Mol Sci 26(6):2509.
Khavinson, V. et al. (2020) — AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism.
The references section of this page cites 5 primary papers published between 2017 and 2025 — a limited but non-trivial record. Every citation is linked to its PubMed or DOI record so it can be read rather than taken on trust, and the summaries above describe what those papers report rather than what the compound is claimed to do.
Research compounds attract claims that outrun their evidence. Below are the ones most often encountered for Epitalon Spray, set against what the papers cited on this page actually report. Where the record is thin or contested, that is stated rather than smoothed over.
Also called
Epitalon Spray is also referred to as epithalon, epithalamin.
Preclinical only
Epitalon Spray is commonly described online in connection with slowing ageing and extending lifespan. In the research literature the same compound is filed under regulatory peptide signaling models, telomere-associated pathway research and cellular signaling framework investigations.
The 5 papers cited on this page, published between 2017 and 2025 (1 in animal models and 1 review) describe laboratory and animal work. None reports a controlled trial in humans. Findings in cell culture or in a rodent model describe what happened in that system; they do not establish that the same occurs in humans, and this compound is not approved for human use.
Nothing above is a statement of what this material does. It is a summary of what has been published and what has not. Eppix Labs supplies research materials only and provides no dosing, administration or protocol guidance.
Verification for Epitalon Spray is per lot, not per product. The current 10mg lot EPIT-CA-26G-10 returned 98.728% purity, 11.56 mg measured, 115.6% of the labelled 10 mg, assayed by Janoshik. Those figures are the laboratory's, published in full rather than reduced to a badge.
The lot code printed on the vial matches the code on the certificate for Epitalon Spray. Matching the two is what confirms the unit in hand came from the batch that was tested — a certificate not tied to a lot code proves nothing about any particular unit.
Researchers who buy Epitalon Spray in Canada through Eppix Labs receive the lot described by the certificate above: the code printed on the vial label is the code on the certificate, and both are searchable on the batch verification page.
Epitalon Spray ships as a prepared solution rather than as lyophilized powder, so it is already past the point at which a powder would be reconstituted. That shortens handling but tightens storage: a compound in solution is less stable than the same compound dry, and refrigeration from arrival onward is the relevant control.
The stability window for a solution is shorter than the shelf life of a sealed lyophilized vial of the same compound. Records for laboratory work in this format should note the date the unit was opened, not only the date it was received.
Vials may appear empty on arrival. Lyophilized material collects at the base of the vial and is often not visible until the vial is inspected under direct light.
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Have questions about batch verification, documentation, or research specifications? Our team is available to assist with product and compliance inquiries.