Research Use OnlyAll materials supplied for laboratory research within Canada
Chemical Structure
CAS
1401708-83-5
Formula
C27H44N4O5
Mol. weight
504.7 g/mol
Form
Lyophilized powder
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Dihexa 10 mg
Dihexa Canada — 10 mg Lyophilized Vials
Angiotensin IV Analogue
Also known as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
Dihexa is a synthetic angiotensin IV–derived peptidomimetic studied in research for procognitive and synaptogenic activity.
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Purity VerifiedLab TestedSecure
Research Use Only
This product is intended strictly for laboratory research use within Canada. It is not approved by Health Canada for the diagnosis, treatment, cure, or prevention of any disease. Not for human or veterinary use.
By purchasing, you confirm the material will be used solely for lawful research purposes in accordance with applicable Canadian regulations.
Dihexa is a synthetic angiotensin IV–derived peptidomimetic studied in research for procognitive and synaptogenic activity.
Experimental models examine its interaction with the hepatocyte growth factor (HGF)/c-Met system under controlled laboratory conditions.
Purity
Third-party tested for purity, ID, quantity.
Coming Soon
The certificate of analysis for the 10mg lot is being finalised and will be published here as soon as the lab returns it.
Dihexa is a small-molecule analogue derived from angiotensin IV, characterized in research for its synaptogenic effects and metabolic stability relative to the parent peptide. Investigations have focused on its dependence on the HGF/c-Met receptor system for procognitive activity.
Preclinical studies have evaluated synapse formation and cognitive-model endpoints under structured conditions.
History
Dihexa emerged from structure–activity research on angiotensin IV analogues aimed at producing metabolically stable, blood–brain-barrier-penetrant compounds for neurodegeneration research.
Work at the angiotensin IV/HGF interface established its synaptogenic profile in laboratory models.
Key Research Areas
Research into dihexa focuses on synaptogenesis and the HGF/c-Met signaling system. Frameworks evaluate angiotensin IV analogue pharmacology and cognitive-model endpoints under controlled preclinical conditions.
2 of the 4 areas below are addressed directly by a paper cited on this page.
HGF/c-Met signaling models
No paper cited on this page reports on hgf/c-met signaling models. This heading marks where Dihexa is discussed in the category rather than a question the cited literature answers, and it is worth knowing which of these areas has work behind it and which does not.
Synaptogenesis research frameworks
No paper cited on this page reports on synaptogenesis. This heading marks where Dihexa is discussed in the category rather than a question the cited literature answers, and it is worth knowing which of these areas has work behind it and which does not.
Angiotensin IV analogue pharmacology
Addressed on this page by Benoist 2014, Wright 2015. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.
Benoist, CC. et al. (2014) — The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system
Wright, JW. et al. (2015) — The development of small molecule angiotensin IV analogs to treat Alzheimer's and Parkinson's diseases
Cognitive-model endpoint studies
Addressed on this page by Benoist 2014. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.
Benoist, CC. et al. (2014) — The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system
The references section of this page cites 3 primary papers published between 2014 and 2015 — a thin record. Every citation is linked to its PubMed or DOI record so it can be read rather than taken on trust, and the summaries above describe what those papers report rather than what the compound is claimed to do.
Dihexa is frequently listed as a peptide by suppliers in this market. It is not one. The structure published on this page is the compound's actual chemistry, and research on it should be read against its own class rather than against peptide literature.
Research compounds attract claims that outrun their evidence. Below are the ones most often encountered for Dihexa, set against what the papers cited on this page actually report. Where the record is thin or contested, that is stated rather than smoothed over.
Also called
Dihexa is also referred to as dihexa, and technically as N-hexanoic-Tyr-Ile-(6) aminohexanoic amide.
Preclinical only
Dihexa is commonly described online in connection with weight loss, appetite suppression and fat reduction. In the research literature the same compound is filed under HGF/c-Met signaling models, synaptogenesis research frameworks and angiotensin IV analogue pharmacology.
The 3 papers cited on this page, published between 2014 and 2015 describe laboratory and animal work. None reports a controlled trial in humans. Findings in cell culture or in a rodent model describe what happened in that system; they do not establish that the same occurs in humans, and this compound is not approved for human use.
Nothing above is a statement of what this material does. It is a summary of what has been published and what has not. Eppix Labs supplies research materials only and provides no dosing, administration or protocol guidance.
Every lot of Dihexa is independently assayed before it is released, and the certificate for the lot shipped is published rather than summarised. Where a certificate for a current lot is not yet posted, the lot has not yet been released against it.
Researchers who buy Dihexa in Canada through Eppix Labs receive a batch-labelled vial whose certificate is published against that lot code, so the material can be matched to its analysis rather than to a generic specification.
−20 °C long-term; stable at room temperature in transit
After reconstitution
2–8 °C
Light
Protect from UV and direct light
Freeze-thaw
Avoid repeated cycles
Vehicle
Solvent selection depends on the compound; consult the published literature
Format
Lyophilized powder
Dihexa is supplied as lyophilized powder. It is not a peptide, and solvent behaviour follows from its own chemistry rather than from the aqueous-vehicle conventions that apply to peptide material — the published literature for this compound is the reference for solvent selection, not a general peptide protocol.
Dry storage below freezing and protection from light are the general controls. As with any lyophilized material, the powder frequently sits as a thin film at the base of the vial and is easy to mistake for an empty vial before inspection.
Vials may appear empty on arrival. Lyophilized material collects at the base of the vial and is often not visible until the vial is inspected under direct light.
1 × sealed glass vial in the strength selected (10mg / Single Vial, 10mg / 5-Pack, 10mg / 10-Pack available), batch-labelled
Batch documentation for the lot shipped, once its certificate is published
Discreet outer packaging with no product names on the exterior
Canada Post Xpresspost, tracked, typically 1–2 business days from Canadian stock
Not included
Bacteriostatic water or any other reconstitution vehicle
Syringes, needles or filters
Dosing, administration or protocol guidance of any kind
Reconstitution materials are sourced separately. The reconstitution calculator on this site works out concentrations for a given volume, but it is an arithmetic tool for laboratory record-keeping and not a protocol.
No. Eppix Labs products are supplied exclusively for laboratory research. We do not provide dosing, administration, or usage guidance.
Each unit contains the labeled quantity of dihexa. Independent third-party analysis verifies purity, identity, and net content per batch.
The unit contains only the research compound. Any laboratory materials required for reconstitution or experimental procedures must be sourced separately.
Duration depends entirely on research design, storage conditions, and laboratory protocol.
Benoist, CC. et al.(2014)
The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system
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Have questions about batch verification, documentation, or research specifications? Our team is available to assist with product and compliance inquiries.