Acetyl-L-carnitine (AICAR) is the acetylated ester of L-carnitine, studied in research for its role in mitochondrial fatty-acid transport and neurometabolic signaling.
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Research Use Only
This product is intended strictly for laboratory research use within Canada. It is not approved by Health Canada for the diagnosis, treatment, cure, or prevention of any disease. Not for human or veterinary use.
By purchasing, you confirm the material will be used solely for lawful research purposes in accordance with applicable Canadian regulations.
Acetyl-L-carnitine (ALCAR) is the acetylated ester of L-carnitine, studied in research for its role in mitochondrial fatty-acid transport and neurometabolic signaling.
Experimental models examine its influence on cellular energy metabolism and neuroprotective pathways under controlled laboratory conditions.
Acetyl-L-carnitine is an endogenous compound that facilitates the transport of acetyl groups and fatty acids across mitochondrial membranes. Research has examined its neurometabolic activity, including effects on energy metabolism, cholinergic signaling, and neuroprotection in cellular and animal models.
Studies span developing-brain, dementia, and peripheral-nerve research frameworks under structured conditions.
History
Carnitine and its acetylated ester were characterized during investigations of mitochondrial fatty-acid metabolism. ALCAR became a recurring subject in neurobiology research owing to its central-nervous-system activity.
Subsequent studies expanded into cognitive, neuropathic, and metabolic models.
Key Research Areas
Research into acetyl-L-carnitine focuses on mitochondrial energy metabolism and neuroprotection. Frameworks evaluate fatty-acid transport, cholinergic signaling, and neurometabolic endpoints under controlled in vitro and preclinical conditions.
1 of the 4 areas below are addressed directly by a paper cited on this page.
Mitochondrial energy-metabolism models
No paper cited on this page reports on mitochondrial, energy or metabolism. This heading marks where AICAR is discussed in the category rather than a question the cited literature answers, and it is worth knowing which of these areas has work behind it and which does not.
Neuroprotection research frameworks
Addressed on this page by Ferreira 2017. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.
Ferreira, GC. et al. (2017) — L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain
Cholinergic signaling studies
No paper cited on this page reports on cholinergic. This heading marks where AICAR is discussed in the category rather than a question the cited literature answers, and it is worth knowing which of these areas has work behind it and which does not.
Neurometabolic endpoint investigations
No paper cited on this page reports on neurometabolic or endpoint. This heading marks where AICAR is discussed in the category rather than a question the cited literature answers, and it is worth knowing which of these areas has work behind it and which does not.
The references section of this page cites 3 primary papers published between 2016 and 2020 — a thin record. Every citation is linked to its PubMed or DOI record so it can be read rather than taken on trust, and the summaries above describe what those papers report rather than what the compound is claimed to do.
AICAR is frequently listed as a peptide by suppliers in this market. It is not one. The structure published on this page is the compound's actual chemistry, and research on it should be read against its own class rather than against peptide literature.
Research compounds attract claims that outrun their evidence. Below are the ones most often encountered for AICAR, set against what the papers cited on this page actually report. Where the record is thin or contested, that is stated rather than smoothed over.
Also called
AICAR is also referred to as ALCAR, acetyl carnitine, and technically as Acetyl-L-Carnitine (ALCAR).
Preclinical only
AICAR is commonly described online in connection with weight loss, appetite suppression and fat reduction. In the research literature the same compound is filed under mitochondrial energy-metabolism models, neuroprotection research frameworks and cholinergic signaling studies.
The 3 papers cited on this page, published between 2016 and 2020 describe laboratory and animal work. None reports a controlled trial in humans. Findings in cell culture or in a rodent model describe what happened in that system; they do not establish that the same occurs in humans, and this compound is not approved for human use.
Nothing above is a statement of what this material does. It is a summary of what has been published and what has not. Eppix Labs supplies research materials only and provides no dosing, administration or protocol guidance.
Verification for AICAR is per lot, not per product. The current 50mg lot AIC-CA-26C-02 returned 99.97% purity, 52.34 mg measured, 104.7% of the labelled 50 mg, assayed by Testides. Those figures are the laboratory's, published in full rather than reduced to a badge.
Purity is half the number. It states what fraction of the material in the vial is AICAR; it says nothing about how much material is in the vial, and a short-filled vial can return a purity result that is entirely accurate. The figure that answers the second question is measured mass against expected content — for AICAR, this lot measured 104.7% of its labelled 50 mg. Both numbers are published for every lot, whichever way they fall.
The lot code printed on the vial matches the code on the certificate for AICAR. Matching the two is what confirms the unit in hand came from the batch that was tested — a certificate not tied to a lot code proves nothing about any particular unit.
Researchers who buy AICAR in Canada through Eppix Labs receive the lot described by the certificate above: the code printed on the vial label is the code on the certificate, and both are searchable on the batch verification page.
−20 °C long-term; stable at room temperature in transit
After reconstitution
2–8 °C
Light
Protect from UV and direct light
Freeze-thaw
Avoid repeated cycles
Vehicle
Solvent selection depends on the compound; consult the published literature
Format
Lyophilized powder
AICAR is supplied as lyophilized powder. It is not a peptide, and solvent behaviour follows from its own chemistry rather than from the aqueous-vehicle conventions that apply to peptide material — the published literature for this compound is the reference for solvent selection, not a general peptide protocol.
Dry storage below freezing and protection from light are the general controls. As with any lyophilized material, the powder frequently sits as a thin film at the base of the vial and is easy to mistake for an empty vial before inspection.
Vials may appear empty on arrival. Lyophilized material collects at the base of the vial and is often not visible until the vial is inspected under direct light.
1 × sealed glass vial in the strength selected (50mg / Single Vial, 50mg / 5-Pack, 50mg / 10-Pack available), batch-labelled
The batch-linked Certificate of Analysis for the exact lot shipped
Discreet outer packaging with no product names on the exterior
Canada Post Xpresspost, tracked, typically 1–2 business days from Canadian stock
Not included
Bacteriostatic water or any other reconstitution vehicle
Syringes, needles or filters
Dosing, administration or protocol guidance of any kind
Reconstitution materials are sourced separately. The reconstitution calculator on this site works out concentrations for a given volume, but it is an arithmetic tool for laboratory record-keeping and not a protocol.
No. Eppix Labs products are supplied exclusively for laboratory research. We do not provide dosing, administration, or usage guidance.
Each unit contains the labeled quantity of alcar. Independent third-party analysis verifies purity, identity, and net content per batch.
The unit contains only the research compound. Any laboratory materials required for reconstitution or experimental procedures must be sourced separately.
Duration depends entirely on research design, storage conditions, and laboratory protocol.
Ferreira, GC. et al.(2017)
L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain
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Have questions about batch verification, documentation, or research specifications? Our team is available to assist with product and compliance inquiries.